Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: Epigenetic drug library screening identified an LSD1 inhibitor to target UTX-deficient cells for differentiation therapy

Fig. 2

Validation of SP2509 in specifically inducing the differentiation of Utx KO HSPCs. a, b Representative flow plots showing cKit (a) and Mac-1 (b) staining in vehicle-treated Utx WT or KO HSPCs from three independent experiments. c, d Flow plots showing cKit (c) and Mac-1 (d) staining in SP2509-treated Utx WT and KO HSPCs. e–h Percentage of cKit+ (e) or Mac-1+ (g) populations in Utx WT and KO HSPCs treated with vehicle or SP2509. Corresponding fold changes of SP2509 vs vehicle-treated Utx WT or KO HSPCs are shown in f (cKit) and h (Mac-1). n = 3. i–l MFI of cKit (i) or Mac-1 (k) staining in Utx WT and KO HSPCs treated with vehicle or SP2509. Corresponding fold changes are shown in j (cKit) and l (Mac-1). n = 3. Error bars represent s.d. *p < 0.05; **p < 0.01; ***p < 0.001

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