Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Epigenetic drug library screening identified an LSD1 inhibitor to target UTX-deficient cells for differentiation therapy

Fig. 3

SP2509 treatment reversed the global effect of Utx deficiency on the transcriptome of HSPCs. a, b Unsupervised clustering (a) and principal component analysis (PCA) (b) of RNA-seq data from Utx WT and KO HSPCs treated with vehicle or SP2509 for 12 h. c Heatmap of differentially expressed genes in Utx WT or KO HSPCs measured by RNA-seq. d Heatmap of differentially expressed genes in Utx KO HSPCs treated with vehicle or SP2509 for 12 h

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