Fig. 2: PARP1 activation susceptibility to MEK inhibition in stimulated cultured cortical neurons. | Signal Transduction and Targeted Therapy

Fig. 2: PARP1 activation susceptibility to MEK inhibition in stimulated cultured cortical neurons.

From: Signal-induced PARP1-Erk synergism mediates IEG expression

Fig. 2

PARP1 activation, as measured by a shift in the PARP1 isoelectric point (pI) and that of its substrate histone H1, in cultured cortical neurons subjected to high-frequency electrical stimulation (100 Hz; induces synaptic potentiation) was prevented by either MEK or PARP inhibitors (U0126 and PJ-34, respectively) (from ref. 20)

Back to article page