Fig. 4: PARP1-Erk synergism mediates IEG expression. | Signal Transduction and Targeted Therapy

Fig. 4: PARP1-Erk synergism mediates IEG expression.

From: Signal-induced PARP1-Erk synergism mediates IEG expression

Fig. 4

A schematic diagram (in red) indicating the regulation of IEG expression by PARP1-Erk synergism as part of a signal transduction network (in gray and black) that mediates synaptic plasticity, MEF proliferation, and newborn cardiomyocyte development. (poly-ADP-ribosylated PARP1 and histone H1: pADPr-PARP1 and pADPr-H1, respectively; phosphorylated Erk and Elk1: pErk and pElk1, respectively; poly-ADP-ribosylated PARP1 bound to phosphorylated Erk; pADPr-PARP1 pErk)

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