Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: The effect of selective serotonin reuptake inhibitors on cognitive function in patients with Alzheimer’s disease and vascular dementia: focusing on fluoxetine with long follow-up periods

Fig. 1

Forest plot of comparisons. a Forest plot of age comparison; there is no age difference between the SSRI and placebo groups (MD = −0.86, 95% CI: −1.76–0.03, P = 0.06). No significant heterogeneity existed (I2 = 0%, P = 0.89) b Forest plot of overall MMSE; there was a significant difference between the SSRI and placebo groups (MD = 0.84, 95% CI: 0.32–1.37, P = 0.002). c Fluoxetine significantly improved cognitive function in clinical practice (MD = 1.16, 95% CI: 0.41–1.90, P = 0.002). Significant heterogeneity existed (I2 = 88%, P < 0.00001). d There was no significant difference between nonfluoxetine SSRIs versus the placebo (MD = 0.58, 95% CI: −0.17–1.33, P = 0.13)

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