Fig. 4
From: Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
MiR-124 NPs promote neurogenesis in PD. a DCX/Ki67 and b GFAP/Ki67 and in miR-124 NP-treated cultures. c Jagged1. d Sox9. e Schematic representation of miR-124 NP effects in in vitro and in vivo study. f Therapeutic effect of miR-124 NPs on the total number of NeuN+/BrdU+ cells in healthy mice or the 6-OHDA mouse model of PD. g NeuN (red) BrdU (green), and Hoechst (blue) staining in the striatum of the 6-OHDA mouse model treated with saline or miR-124 NPs. h Apomorphine-induced rotation test illustrates net rotation to the contralateral side of healthy or PD mice. Data are expressed as the mean ± SEM (n = 4–6 mice) #P < 0.05, **P < 0.01, ***P < 0.001. Reproduced with permission from ref. 132
