Fig. 8
From: Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
Different polymeric architectures for controlled release and tumor treatment. a In vitro drug release from different generations of CD and its grafting to polyurethane. b Relative changes in the tumor volume with time treated with indicated patch systems. c Histopathological images of hematoxylin and eosin-stained liver in treatment groups. d Polymer design and preparation of different generations from CD and linear polymers. e Cumulative release percentage of paclitaxel from CD, subsequent generations presenting a sustained release of the drug from a superstructure. f Images of mice tumor at the initial day and after treatment with Mod-Gel-d and Gel-d at different time intervals. g Relative changes in the tumor volume for different gels with time. h Plasma paclitaxel concentration versus time for Mod gel-d and pure drug after intravenous administration. Reproduced from ref. 255,256
