Table 1 Some of targeted therapies in control and treatment of asthma

Cell surface protein

Siglec-8

Apoptosis of eosinophils

High

^{294, 295}

CD300a

Activation of inhibitory receptor

High

²⁹⁶

α₄β₁, α₄β₇

Increase blood eosinophils and inhibits their tissue accumulation

High

²⁹⁷

CCR3

Block chemokine-induced eosinophils

High

²⁹⁸

CXCR2

Reduce neutrophils

Low

¹⁶

CD52

Deplete eosinophils

High

²⁹⁹

EMR1

Deplete primate eosinophils

High

³⁰⁰

CRTH2

Reduce tissue eosinophils

High

³⁰¹

Transcription factor

GATA3

Reduce IL-5

High

³⁰²

Soluble mediator antagonist

Eotaxin-1

Inhibit eosinophil migration

High

^{303, 304}

IgE

Reduces allergic inflammation and exacerbations and airway obstruction

High

^{305, 306}

IL-4

Reduce allergic inflammation

High

^{307, 308}

IL-13

Reduce airway obstruction and cough

High

^{309, 310}

Interleukin-17RA

Reduce Th17 response

Low

³¹¹

TSLP

Reduce eosinophils and allergic inflammation

High

³¹²

PGD2

improved Lung function

High

^{313, 314}