Table 4 Role of the cytokines in pathophysiology of asthma and related signaling molecules

From: Targeting cell signaling in allergic asthma

Cytokine

Function

Signaling pathway

References

IL-4

AHR

JAK-STAT, ERK, p38 MAPK, JNK and mTOR

17,18,19,20,– 21, 154, 158, 186, 188, 197, 199, 202, 204

IL-5

Eosinophilic inflammation

IL-13

Mucus production

IL-13

Goblet cell hyperplasia

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