Table 4 The roles of exosomal lncRNAs in the proliferation, metastasis, invasion, and drug resistance of lung cancer cells
From: The roles of exosomal miRNAs and lncRNAs in lung diseases
Groups | Sample | Exosomal lncRNA | Expression in lung cancer | Functions | References |
|---|---|---|---|---|---|
NSCLC vs. HC | Serum | MALAT-1 | Upregulation | Promote proliferation, migration, and reduce apoptosis of lung cancer cell | Zhang et al.122 |
TGF-β-treated vs. non-TGF-β-treated A549 cells | Cell culture | lnc-MMP2-2 | Upregulation | Promote metastasis, invasion of cancer cells, and reduce permeability of vascular endothelial cells | Wu et al.30 |
Erlotinib-resistant vs. sensitive NSCLC patients/cells | Serum, cell culture | RP11-838N2.4 | Upregulation | Promote erlotinib resistance acquisition of lung cancer cells | Zhang et al.128 |
Gefitinib-resistant vs. sensitive NSCLC cells | Cell culture | lncRNA H19 | Upregulation | Promote gefitinib resistance acquisition of NSCLC cells | Lei et al.129 |
Lung cancer vs. healthy mice/cells | Serum, cell culture | GAS5 | Downregulation | Promote angiogenesis in lung cancer | Cheng et al.124 |
