Fig. 4 | Signal Transduction and Targeted Therapy

Fig. 4

From: Integrative analysis of DNA methylation and gene expression identified cervical cancer-specific diagnostic biomarkers

Fig. 4

Identification of cervical cancer-specific biomarkers. a The workflow used to identify cervical cancer-specific methylation markers (GDC: Genomic Data Commons; CESC: cervical squamous cell carcinoma and endocervical adenocarcinoma). b Hierarchical clustering of the 388 candidate CpGs in samples from TCGA, GSE38266, GSE46306, and GSE68339. c Receiver-operating characteristic (ROC) curve and AUC values for TCGA data with tenfold cross-validation. d The distribution of the methylation levels for the four final selected markers in TCGA data of cervical tumors, normal tissues, and other cancers

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