Fig. 1
a Overview of the proteotranscriptomics atlas of human placenta samples. b The Spearman correlation coefficients correlation across each gene product. Positively correlated genes and their enriched pathways are shown in red, and negatively correlated genes and their enriched pathways are shown in green. Multiple-test adjusted p values are provided in the parentheses following the KEGG pathway names. c The number of common DEPs and DEMs. Each column represents the number of proteins intersecting with corresponding mRNAs. d The upper heatmap shows the proportion of placental DEM and co-DEGs. The lower panel shows the odds ratios and 95% confidence levels of Fisher’s exact test in each cancer type. e Clustering of cancer types with similar tissue origins based on the placental co-DEGs. f Subcellular location of placental expressed proteins, the numbers in brackets represent the number of proteins corresponding to the subcellular localization. g ssGSEA for placental proteome profiles and immune-related pathways. h The bubble chart displays the results of regression analysis of the key immunomodulators and cancer immunity scores (upper) and CYT (lower). Each column represents one cancer type, and each row represents a key immunomodulator. i Upper, the number of immunomodulators significantly associated with the patient prognosis across cancer types. And below heatmap represents the Cox regression significance of each key immunomodulators
