Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: CD146, from a melanoma cell adhesion molecule to a signaling receptor

Fig. 1

Schematic representation of CD146 as the receptor of proteins related in the ECM. CD146-ligand binding-induced events are indicated by the red arrows. The immunoglobulin domains of CD146 are illustrated as balls and the pink and blue color represent the V and C2 immunoglobulin domains, respectively. The green rectangle and the yellow trapezoid represent the PKC phosphorylation site and the dileucine motif, respectively

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