Fig. 2
From: Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals
Comparison of V gene usage of IGH, TRA, and TRB among SPs, MPs, and HCs. a Principal component analysis (PCA) for IGHV-gene usage and TRAV or TRBV-gene usage in SPs (S1–S5), MPs (M1–M4), and HCs (H1–H5). b Volcano plot representing differences of IGHV-gene usage in BCR repertoires or TRAV/TRBV-gene usage of TCR repertoires. Positive fold-change values denote more frequent IGHV genes or TRAV/TRBV genes in COVID-19 patients. Genes with P value < 0.05 are displayed in red. Genes with a P value > 0.05 but fold-change (FC) value > 1.5 are displayed in blue. c Heatmap of reprehensive gene segments enriched in SPs or MPs compared with in HCs. Colors denote frequencies of each V gene segment used in each sample. The V genes overpresented in SPs or MPs (P value < 0.05) are indicated using a blue or a green star, respectively. Other known biasedly used gene segments related to virus-specific antibodies are marked using relevant virus name (EBV, EBoV, Flu, CMV, HCMV, and SIV). Genes consistent with another COVID-19 recovered patient study10 are denoted with a cross
