Table 1 Regulation of CHI3L1 expression

Gene level

miR-342-3p

B16F10 cell lines

↓

²⁶³

miR-125a-3p

A549, H460 cell lines

↓

²⁶⁴

miR-24

MC3T3-E1 cell, U937 cell

↓

^55,56,149

miR-449a

HEPG2 cells

↓

⁵⁸

Cellular level

ECM

↑

²⁶⁵

Cytokines

Th1 (IFN-γ), Th2 (IL-4, IL-13),

TNFα, IL-1β

SW480 and T84 cell lines

↑

^29,60,118

IL-6, IL-17, IL-18, TNFα

Chondrocytes, macrophages

↑

^266,267,268

IL-1β, TGF-β

Chondrocytes

↓

¹¹

Th1 (IFN-γ)

Macrophages

↑

¹³

Th2 (IL-4)

Macrophages

↓

¹³

TNFα

HEPG2 cells,

↑

⁵⁸

Human skeletal muscle cells

↑

⁹

TNFα, Th1 (IFN-γ),

U87 MG cell lines

↓

⁶

Th2 (IL-4, IL-13)

Growth factors

IGF-I, IGF-II

Guinea pig chondrocytes

↑

^2,12

bFGF

U87 MG cell lines

↓

⁶

Drugs

Dexamethasone,

Macrophages

↓

¹³

Etoposide ceramide,

U87 MG cell lines

↓

^6,258

Antioxidant, resveratrol

Stress

Hypoxia, confluence, p53 inhibition,

serum depletion, lonizing radiation

U87 MG cell lines

↑

⁶

Hypoxia

Bronchial epithelial cells

↓

²⁶⁹