Fig. 10 | Signal Transduction and Targeted Therapy

Fig. 10

From: Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials

Fig. 10

The Keap1/Nrf2 interactions and interactions. a The Keap1–Nrf2-ARE pathway. Under basal conditions, Nrf2 binds to Keap1 and is degraded by proteasomes. Under oxidative stress, Nrf2 escapes the degradation mediated by Keap1 and transfers to nucleus, binding with ARE and Maf protein to initiate the transcription of antioxidative and cytoprotective genes. b The chemical structures of inhibitors of Keap1/Nrf2

Back to article page