Table 2 The advantages and disadvantages of three types of PPI modulators

From: Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials

Small molecules

Peptides

Antibodies

Advantages

  

Penetrate cell membrane

Oral administration

Target specificity

High affinity

Strong target specificity

High efficiency

Disadvantages

  

Side effects (low selectivity)

Short half-life

Poor oral administration

Unstable physicochemical properties

Poor solubility

Side effects (immunogenicity)

Generally act on extracellular targets (huge molecular weight)

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