Table 3 Peptide inhibitors of MDM2/p53 interaction reported by Chang et al.

From: Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials

Name

Sequence

Ki (nM)

ATSP-1800

Ac-Gln-Ser-Gln-Gln-Thr-Phe-R8-Asn-Leu-Trp-Arg-Leu- Leu-S5-Gln-Asn-NH2

25.9

ATSP-3848

Ac-Leu-Thr-Phe-Glu-His-Tyr-Trp-Ala-Gln-Leu-Thr-Ser-NH2

14.6

ATSP-3900

Ac-Leu-Thr-Phe-R8-His-Tyr-Trp-Ala-Gln-Leu-S5- Ser-NH2

1.0

ATSP-4641

Ac-Leu-Thr-Phe-R8-Ala-Tyr-Trp-Ala-Gln-Leu-S5- Ser-NH2

4.9

ATSP-6935

Ac-Leu-Thr-Phe-R8-Glu-Tyr-Trp-Ala-Gln-Leu-S5- Ser-NH2

1.2

ATSP-7041

Ac-Leu-Thr-Phe-R8-Glu-Tyr-Trp-Ala-Gln-Cba-S5- Ser-Ala-Ala-NH2

0.9

ATSP-7342

Ac-Leu-Thr-Ala-R8-Glu-Tyr-Trp-Ala-Gln-Cba-S5- Ser-Ala-Ala-NH2

536

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