Table 4 Some peptide inhibitors of Keap1/Nrf2 interaction

From: Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials

Name

Sequence

IC50 (nM)

P1

H-LDEETGEFL-OH

3480 ± 920

P2

H-AFFAQLQLDEETGEFL-OH

163 ± 11

P3

Ac-LDEETGEFL-OH

194 ± 49

P4

Ac-NAETGEF-OH

8230 ± 262

P5

Ac-DAETGEW-OH

558 ± 53

P6

St-DPETGEL-OH

22 ± 3

P7

YGRKKRRQRRRLQLDEETGEFLPIQ

24

Back to article page