Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: Advances in targeted therapy for esophageal cancer

Fig. 2

EGFR-related, VEGFR-related, HER2-related, and c-MET-related signaling pathways. These receptors on the cell membrane are activated by binding to the corresponding ligands (therapeutic drugs), which lead to autophosphorylation of tyrosine residues. The signaling pathways include the PI3K/AKT/mTOR, Src/FAK, Ras/Raf/MEK/ERK, Ras/MEKK-1/MKK-7/JNK, and PLC-γ/PKC pathways. By regulating these pathways, targeted drugs can ultimately affect the survival, adhesion, proliferation, angiogenesis, movement, and invasion of cancer cells

Back to article page