Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: SARS-CoV-2-specific T-cells in unexposed humans: presence of cross-reactive memory cells does not equal protective immunity

Fig. 1

Pre-existing cross-reactive T-cell immunity could impact COVID-19 disease severity. Mateus et al. show the presence of pre-existing T-cell immunity in pre-pandemic donors (donor a–d), induced by one or multiple of the seasonal HCoVs (left part of figure). It is still unclear how pre-existing immunity impacts disease severity (or outcome) after SARS-CoV-2 exposure (right part of the figure). Different pre-exposure history could lead to different cross-reactive T-cell responses and different disease severity

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