Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Targeting nuclear acid-mediated immunity in cancer immune checkpoint inhibitor therapies

Fig. 3

cGAS/STING- mediated signal transduction pathway. As the cytosolic DNA sensors, cGAS recognizes dsDNA from DNA viruses or dsDNA created by retroviruses. Following the detecting of DNA, cGAS synthesizes the second messenger cGAMP, which then binds to and activates STING on the endoplasmic reticulum (ER). In addition, STNG can sense CDNs. Activated STING translocates from ER to Golgi to form a complex with TBK1 or IKK. The activation of TBK1 or IKK induces the expression of type I IFN genes and other pro-inflammatory cytokines through the TBK1-IRF3/7 axis and NF-κB

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