Table 2 Results of univariate and multivariate analysis of clinicopathological factors for recurrence-free survival (Cox proportional hazard model)

From: CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1

Variables

Univariate analysis

Multivariate analysis (circRNA-SORE)

Multivariate analysis (YBX1)

HR

95% CI

p value

HR

95% CI

p value

HR

95% CI

p value

Age (Old/Young)

0.987

0.958−1.015

0.356

      

Gender (Female/Male)

1.641

0.496−5.431

0.417

2.830

0.756−10.591

0.122

   

HBV (+/−)

1.661

0.795−3.472

0.177

      

Fibrosis (+/−)

2.035

0.869−4.764

0.101

2.648

1.059−6.618

0.037

2.034

0.860−4.811

0.106

Stagea (Late/ Early)

1.415

0.626−3.202

0.404

1.938

0.814−4.612

0.135

   

Micro-vascular invasion (Present/Absent)

1.597

0.785−3.250

0.196

   

1.998

0.958−4.169

0.065

circRNA-SOREb (High/ Low)

2.053

0.997−4.227

0.051

2.281

1.074−4.845

0.032

   

YBX1c (++/+++ vs. −/+)

2.563

1.214−5.414

0.014

   

2.972

1.380−6.402

0.005

  1. As a positive correlation of YBX1 protein level and circRNA-SORE expression level was observed in Table 1, to avoid interations between factors, the multivariate analyses were performed respectively for circRNA-SORE and YBX1
  2. aBureau of Medical Administration, National Health and Family Planning Commission of the People’s Republic of China41
  3. bThe median circRNA-SORE expression was used as cut-off for high- and low-expression groups
  4. cYBX1 levels were defined by immunohistochemical staining
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