Fig. 2
From: CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells
SARS-CoV-2 employs the CD147 receptor for host cell entry. a, b Left, Vero E6 and BEAS-2B cells were transfected with shRNA for CD147 gene silence; the gene expression level was detected by real-time PCR. Right, SARS-CoV-2 infection test was performed in Vero E6-shCD147 and BEAS-2B-shCD147 cells. At 48 h after infection, the virus copy number was detected with quantitative PCR (**p < 0.01, ***p < 0.001, two-tailed t-test, mean ± SEM). c, d Left, CD147 expression level was detected by real-time PCR in BEAS-2B-CD147 and BHK-21-CD147 cells. Right, SARS-CoV-2 infection test was performed in BEAS-2B-CD147 and BHK-21-CD147 cells. At 48 h after infection, the virus copy number was detected with quantitative PCR (**p < 0.01, ***p < 0.001, two-tailed t-test, mean ± SEM). e, f The infection efficiency of SARS-CoV-2 pseudovirus was detected by luciferase reporter assay in BEAS-2B-shCD147 and BEAS-2B-CD147 cells (**p < 0.01, ***p < 0.001, two-tailed t-test, mean ± SEM). g SARS-CoV-2 pseudovirus infection of BHK-21-CD147 cells was neutralized by recombinant human CD147 extracellular fragment (**p < 0.01, ***p < 0.001, two-tailed t-test, mean ± SEM)
