Fig. 2
From: The regulation of protein translation and its implications for cancer
The model of protein translation process. Translation is initiated by eIF4F assembly, consists of eIF4A, eIF4E, and eIF4G. The hypophosphorylated form of 4E-BPs competes with eIF4G to bind eIF4E, and phosphorylated eIF2α fails to recover the GTP required for Met-tRNAi, resulting in failure of the formation of eIF4F complexes and inhibits translation. Extension: the initiation complex of cap-dependent translation scans the mRNA from the 5 ‘end to find the first start codon (AUG), and enters the ribosomal P-site via initiator methionyl tRNA (Met-tRNAi). Termination: when the mRNA with stop codon (UAG, UGA, UAA) enters the ribosomal A-site, it can’t be recognized by activated amino acid (aa-tRNA), the translation process is finished
