Table 2 Noncoding RNAs involved in translation regulation
From: The regulation of protein translation and its implications for cancer
Protein | Clinical correlates in cancers | Ref. | |
|---|---|---|---|
microRNA | |||
miR-10b | inhibits HOXD10 translation | promotes the migration and invasion of breast cancer | |
miR-12528 | inhibits IGF1R translation | inhibits cell proliferation and metastasis in lung cancer | |
miR-146a | inhibits c-met translation | inhibits colorectal cancer liver metastasis | |
miR-125b | inhibits PIGF translation | inhibits the angiogenesis of liver cancer | |
miR-143-3p | inhibits BRD2 translation | increases the therapy sensitivity to cisplatin in gastric cancer | |
miR-648 | inhibits MGMT translation | sensitizes gliomas to temozolomide treatment | |
miR-675-5p | inhibits TP53 translation | promotes the development of colorectal cancer | |
miR-10a | promotes RP translation | promotes the overall protein translation | |
microRNA&RBP | |||
miR-143 and MSI2 | regulates KRAS protein translation | affects the tumor growth of bladder cancer | |
miR-155-5p and HuR | promotes HuR translation | supports the metastasis of colorectal cancer | |
miR-330 and HuR | regulates STAT3 translation | cachexia | |
miR-17-19b and HuR | regulates the translation of MYC | ensure the optimal growth of B-cell lymphoma | |
LncRNA | |||
lncRNA-GMAN | promotes ephrin A1 translation | enhances the invasion ability of gastric cancer | |
lncRNA-GMAN | regulates BCL-2, BCL-6, XIAP, e-cadherin, n-cadherin, vimentin, and snail translation | promotes the development of liver cancer | |
lncRNA-MALAT1 | increases TCF7L2 translation | promotes aerobic glycolysis in liver cancer | |
LncNB1 | promotes E2F1 translation | induces neuroblastoma cell proliferation and survival. | |
RP1-5O6.5 (RP1) | attenuates p27kip1 translation | promotes breast cancer cell proliferation and metastasis | |
PYCARD-AS1 | regulates PYCARD translation | antiapoptosis of breast cancer | |
Protein | Cancer | Ref. | |
|---|---|---|---|
LncRNA and RBP | |||
OCC-1 and HuR | regulates the translation of HuR targets | colorectal cancer | |
7SL and HuR | attenuates P53 translation | HeLa | |
lincRNA-p21 and HuR | regulates the translation of JUNB and CTNNB1 | cervical carcinoma | |
lncRNA-TRMP and PTBP1 | regulates P27 translation | A549 cell | |
AFAP1-AS1 and AUF1 | promote translation of ERBB2 | breast cancer | |
Lnc-LBCS and hnRNPK | regulates AR translation | prostate cancer | |
lncRNA-HITT and YB-1 | regulates HIF-1α translation | colon cancer |
LncRNA and microRNA | |||
LINC00460 and miR-149-5p | regulates CUL4A translation | colorectal cancer | |
LINC00346 and miR-34a-5p | regulates the translation of CD44, NOTCH1, and AXL proteins | gastric cancer | |
HOXA11-AS and miR-1297 | regulates EZH2 protein translation | gastric cancer | |
lncRNA H19 and miR-29b-3p | regulates MCL-1 translation | myeloma | |
circRNA | |||
circβ-catenin | generates a new 370 amino acid β-catenin isoform | liver cancer | |
Circ-FBXW7 | encodes a new 21-kDa protein called FBXW7-185aa | gliomas | |
circ-SHPRH | translates a new 17 kDa protein, SHPRH-146aa | gliomas | |
circYap | inhibit the translation of Yap protein | breast cancer | |
circPABPN1 and HuR | regulates the translation of PABPN1 | Hela | |
OIP5-AS1 and HuR | regulates target genes of HuR | — | |
circRNA-MTO1 and TRAF4 | inhibits the translation of Eg5 | breast cancer | |
circ-MALAT1 and miR-6887-3p | enhances JAK2 expression | liver cancer | |
circEIF4G2 and miR-218 | increases HOXA1 translation | cervical cancer | |
