Fig. 5
From: Risk SNP-induced lncRNA-SLCC1 drives colorectal cancer through activating glycolysis signaling
HK2 is the functional target gene of lncSLCC1 in colorectal cancer. a, b CCK8 assays (a) and colony formation assay (b) were measured after transfection with Control, lncSLCC1-smart silencer, and lncSLCC1-smart silencer with HK2 plasmid in DLD-1 cells. c–f Representative images of tumors (c), statistical analysis of tumor volumes (d, e) and tumor weights (f) in nude mice bearing DLD-1 cells in different groups (n = 5, nonparametric Mann–Whitney test). g, h The lactic acid level and ATP production were measured in DLD-1 cells transfected with Control, lncSLCC1-smart silencer, and lncSLCC1-smart silencer with HK2 plasmid. i Representative images and summarized data of 18F-FDG uptake by micro-PET imaging in control shRNA, lncSLCC1 shRNA, and lncSLCC1 shRNA with HK2 virus in xenograft mouse models (inoculated in the armpit of mice, pictures were taken in the layer which showed similar FDG uptake in non-tumor regions among various group). White circles indicated tumor glucose uptake. Maximum uptake values (SUVmax) for xenografts measured by FDG PET were presented, nonparametric Mann–Whitney test
