Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy

Fig. 1

Hallmarks of an immunosuppressive tumor microenvironment. Six hallmarks, including heterogeneity of constitution, lack of tumor antigen, defect of antigen-presenting cell, impairment of T-cell infiltration, activation of an immunosuppressive signaling pathway, and enhancement of immunosuppressive metabolism co-contribute to an immunosuppressive tumor microenvironment

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