Table 6 Potential therapeutic tools for antioxidant treatment during COVID-19
Potential therapeutic | Formula | Targets | Mechanism of action | Refs |
|---|---|---|---|---|
Human recombinant IL-37 | AMP-activated kinase | Increase NO bioavailability and reduces ROS formation | ||
DAQ B1 | Akt | An activator of Akt, and reduces oxidative stress | ||
BMOV | PTPase | An inhibitor of PTPase that activates eNOS and reduces oxidative stress | ||
N-Acetyl-L-cysteine | C5H9NO3S | Endogenous metabolite | A ROS inhibitor | |
VAS2870 | C18H12N6OS | NOX | A pan NOX inhibitor | |
APX-115 | C17H18ClN3O | NOX | An active pan NOX inhibitor | |
Setanaxib | C21H19ClN4O2 | NOX1/4 | A selective NOX1/4 inhibitor | |
gp91ds-tat | C98H190N50O22S | NOX | Reduce ROS formation and platelet activation | |
GLX351322 | C21H25N3O5S | NOX4 | An inhibitor of NOX4 | |
GSK2795039 | C23H26N6O2S | NOX2 | A NOX2 inhibitor |
