Fig. 3: Gene set enrichment analysis (GSEA) showing an immune system remolding at the whole transcriptome level.
From: Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19
a The bubble-pie graphs displaying upregulated and downregulated gene ontology (GO) gene sets enriched by the differentially expressed mRNAs, miRNAs, and lncRNAs. The color refers to the indicated type of transcripts enriched for a gene set. The bubble size maps the sum enrichment scores of all RNA types in a gene set. The X and Y values of a gene set are calculated by REVIGO’s GO semantic space algorithm.69 The ellipses refer to clusters formed by gene sets with a high semantic similarity. b GSEA plot showing the distribution of the upregulated or downregulated gene sets and the enrichment scores based on DEGs for all samples. The heat map shows the core genes in these gene sets of different clinical stages for all samples, mild, moderate and severe groups, respectively. The blue-red gradient square maps the slope of the linear regression equation of Log2 fold change of DEG
