Table 1 Growth factors may contribute to different types of AKI.

From: Potential targeted therapy and diagnosis based on novel insight into growth factors, receptors, and downstream effectors in acute kidney injury and acute kidney injury-chronic kidney disease progression

Model of AKI

Growth factor

Ischemia-reperfusion Injury

BMP-7/EGF/FGF-2/HGF/

IGF-1/TGF-β1/VEGF/PDGF

Folic acid-induced AKI

BMP-7/EGF/FGF-23/HGF/

TGF-β1/VEGF/IGF-1

Cisplatin-induced AKI

BMP-7/TGF-β1/VEGF/

FGF-21/FGF-10/EGF/IGF-1/HGF

Lipopolysaccharide-induced AKI

BMP-7/FGF-2/TGF-β1/HGF/EGF

Mercuric chloride-induced AKI

EGF/IGF-1

Glycerol-induced AKI

HGF/TGF-β1

Colistin-induced AKI

TGF-β1/EGF

Gentamicin-induced AKI

IGF-1/TGF-β1/EGF/PDGF/VEGF

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