Fig. 1: MYH9 promotes stemness properties, migration, invasion, growth, and sorafenib resistance in HCC. | Signal Transduction and Targeted Therapy

Fig. 1: MYH9 promotes stemness properties, migration, invasion, growth, and sorafenib resistance in HCC.

From: Silencing MYH9 blocks HBx-induced GSK3β ubiquitination and degradation to inhibit tumor stemness in hepatocellular carcinoma

Fig. 1

a Western blotting analyses of MYH9 expression in Hep3B, HepG2, PLC/PRF/5, SMMC-7721, Bel-7402, Bel-7404, Huh7, HCCLM3, and LO2 cells. Western blotting and QPCR analyses of MYH9 levels in MYH9-overexpressing HCC cells, MYH9-depleted HCC cells, and control cells. b–f Hepatosphere formation assays (scale bar indicates 20 μm) b, flow cytometry analyses c, immunofluorescence analyses (scale bar indicates 5 μm) d, wound healing assays and transwell assays (scale bar indicates 10 μm) e, EdU incorporation assays (scale bar indicates 10 μm) and colony-formation assays f, and anticancer drug sensitivity tests g in MYH9-overexpressing Huh7 cells, MYH9-depleted HCCLM3 cells, and control cells.

Back to article page