Fig. 6: Immunohistochemical analyses of MYH9, GSK3β, β-catenin, and HBX expression in HCC. | Signal Transduction and Targeted Therapy

Fig. 6: Immunohistochemical analyses of MYH9, GSK3β, β-catenin, and HBX expression in HCC.

From: Silencing MYH9 blocks HBx-induced GSK3β ubiquitination and degradation to inhibit tumor stemness in hepatocellular carcinoma

Fig. 6

a Comparisons of MYH9, GSK3β, and β-catenin expression between HCC and adjacent noncancerous tissues. b Correlations among HBX, MYH9, GSK3β, and β-catenin expression. c Kaplan–Meier survival analysis was performed for HCC patients according to MYH9 expression. d Univariate and multivariate survival analyses of clinicopathological characteristics of hepatocellular carcinoma patients. e Working model of the MYH9/GSK3β/β-catenin-c-Jun regulatory circuit activated by HBX via MYH9-modulated ubiquitination and degradation of GSK3β in Wnt signaling in HCC.

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