Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: A novel silicone derivative of natural osalmid (DCZ0858) induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma via the JAK2/STAT3 pathway

Fig. 2

DCZ0858 promotes DLBCL cell cycle arrest in the G0/G1 phase. a NU-DUL-1 and OCI-LY8 cells were treated with 10 μM DCZ0858 for different times (24 and 48 h), stained with PI, and analyzed by flow cytometry. b Percentages of G0/G1, S, and G2/M phases in the cell cycle are shown in the statistical graph. c After 48 h of treatment with DCZ0858 (20 and 40 μM), the protein extracts from the NU-DUL-1 and OCI-LY8 cells were analyzed by western blotting to determine the changes in the levels of CDK6, CDK4, and cyclin D1 proteins. All data are shown as the means ± S.D. on the basis of triplicate measures; *P < 0.05 and **P < 0.01

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