Fig. 4 | Signal Transduction and Targeted Therapy

Fig. 4

From: A novel silicone derivative of natural osalmid (DCZ0858) induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma via the JAK2/STAT3 pathway

Fig. 4

Mechanism of DCZ0858-induced tumor inhibition. a NU-DUL-1 and OCI-LY8 cells were treated for 48 h with DCZ0858 (20 and 40 μM), and then, the levels of JAK2, phospho-JAK2, PI3K, phospho-PI3K, Akt, phospho-Akt, mTOR, phospho-mTOR, STAT3, phospho-STAT3, c-Myc, and actin were assessed by western blotting. b The gray values for the protein bands represent the mean ± SD of three sets of experimental data. c The expression of JAK2 and STAT3 in a variety of malignancies from the TCGA database. d The expression of JAK2 and STAT3 in DLBCL patients in the Oncomine database. e The expression of STAT3 in DLBCL cells based on individual tumor stages. Additionally, upregulated STAT3 was associated with advanced cancer stages. f The survival curve of the DLBCL patients based on STAT3 expression in the Oncomine database; *P < 0.05

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