Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Exosomes with low miR-34c-3p expression promote invasion and migration of non-small cell lung cancer by upregulating integrin α2β1

Fig. 3

Profiles of miRNA expression in exosomes derived from different cells. a The ratio of the percentage small RNA categories in all reads mapped to noncoding RNA databases. b Venn diagram showing the unique and overlapping miRNAs between exosomes from different cells. c Biological replicates between exosomes from BEAS-2B and A549 cells. d Heatmap diagram of differential miRNA expression between exosomes derived from BEAS-2B cells and A549 cells. Gene expression data were obtained using next-generation sequencing on an Illumina HiSeq 2500 platform. Mean expression values are shown. Red, increased expression; green, decreased expression; and black, mean value. **p < 0.01. e Determination of miR-34c-3p, miR-34c-5p, miR-127-5p, miR-889-3p, miR-3182 and miR-454-5p microRNA levels by quantitative real-time PCR in exosomes from NSCLC cells. Experiments were performed in triplicate

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