Fig. 4 | Signal Transduction and Targeted Therapy

Fig. 4

From: Exosomes with low miR-34c-3p expression promote invasion and migration of non-small cell lung cancer by upregulating integrin α2β1

Fig. 4

Integrin α2β1 protein and exosomal miRNA expression in clinical samples. a Levels of miRNAs in the sera of NSCLC patients and healthy controls. The levels of exosomal miR-34c-3p, miR-34c-5p, miR-889-3p, miR-454-5p, miR-3182, and miR-127-5p in the sera of NSCLC patients (n = 37) and healthy controls (n = 21) were measured by RT-qPCR. Differences in miRNA expression between NSCLC patients and healthy controls were analyzed by nonparametric test, ns no significance, *p < 0.05, **p < 0.01, and ***p < 0.001. b Kaplan-Meier curve analysis of NSCLC patients (n = 37) was performed according to the smoking index. c The protein expression of integrin α2 and β1 in NSCLC tissue samples (n = 50). Immunohistochemistry on the expression of integrin α2 and β1 in 50 human lung adenocarcinoma samples. Three representative staining images are shown, where either integrin α2 or integrin β1 staining was positive (white arrow) or negative (black arrow). ITG A2 Integrin α2, and ITG B1 Integrin β1

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