Fig. 6 | Signal Transduction and Targeted Therapy

Fig. 6

From: Exosomes with low miR-34c-3p expression promote invasion and migration of non-small cell lung cancer by upregulating integrin α2β1

Fig. 6

Inhibition of miR-34c-3p in exosomes induced A549 cell migration by regulating integrin α2β1. a Migration of A549 cells was induced by transfection with miR-34c-3p inhibitor. b Data analysis of a. c A549 cell migration was inhibited by transfection with miR-34c-3p mimics. d Data analysis of c. ns no significance, *p < 0.05, **p < 0.01, and n ≥ 3. e Western blot of integrin α2β1 expression in A549 cells after transfection with miR-34c-3p mimics. f Reduction in the level of miR-34c-3p in exosomes upon transfection with a miR-34c-3p inhibitor in A549 cells. g Induction of A549 cell migration by miR-34c-3p inhibitor-exo. h Data analysis of Fig. 6g. i Western blot analysis of integrin α2β1 expression from different groups, and GAPDH was used as a control to normalize levels. ns no significance, *p < 0.05, **p < 0.01, ***p < 0.001, and n ≥ 3. ITG A2 Integrin α2, and ITG B1 Integrin β1

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