Fig. 1
From: miR-24-3p promotes colon cancer progression by targeting ING1
miR-24-3p promotes colon cancer proliferation and invasion and inhibits colon cancer apoptosis by targeting ING1. a Western blot analysis of ING1 protein levels in 16 paired colon cancer (T) and normal adjacent tissue (N) samples. b Potential binding site of miR-24-3p at the ING1 3′-UTR. c The relative luciferase activities in SW480 transfected with miR-24-3p mimic or inhibitor. d ING1 was negatively regulated by miR-24-3p in SW480 and HT29 cells. e The ING1 plasmid could effectively restored the ING1 protein level suppressed by miR-24-3p. f–i miR-24-3p promotes SW480 proliferation and invasion and inhibits SW480 apoptosis in vitro by targeting ING1 (f) CCK8 assay; (g) Apoptosis assay; (h) Transwell invasion assay; (i) Quantitative analysis of apoptosis and transwell invasion assays. j miR-24-3p promotes colon cancer growth in vivo by targeting ING1. Data are showen as mean ± s.e.m. in (c, f and i) with data points from independent experiment in (c and i). α p < 0.05; αα p < 0.01; ααα p < 0.001
