Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: PIWIL1 governs the crosstalk of cancer cell metabolism and immunosuppressive microenvironment in hepatocellular carcinoma

Fig. 2

PIWIL1 modulates fatty acid oxidation in HCC cells. a Intracellular ATP of PIWIL1-overexpressing HCC cells was significantly higher than that of wild-type cells; Overexpression of PIWIL1 could significantly increase the oxygen consumption rate of HCC cells, as indicated by OCR assay (b, c), while its effect on ECAR of HCC cells was not significance (d, e). Overexpression of PIWIL1 led to the higher value of OCR/ECAR ratio at basal (f) and maximal (g) respiration. h The composition of fatty acid metabolites of wild type and PIWIL1-overexpressing HCC tumors was analyzed by GC-MS, which indicated an increase of C16 intermediates (n = 5). All experiments were performed in triplicate if without particular notice. *p < 0.05; **p < 0.01; ***p < 0.001

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