Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: Targeting Erbin in B cells for therapy of lung metastasis of colorectal cancer

Fig. 2

Expression of Erbin in different types of immune cells and the effects of Erbin deletion on immune cells. a The mRNA level of Erbin in NK cells (NK), Dendritic cells (DC), Monocytes, B cells, T cells, and Neutrophil cells in splenic leukocytes (SPL). b The mRNA level of Erbin in the pro, pre, immature and mature phases of B cells in bone marrow (BM). c The mRNA level of Erbin in Naive B, Memory B, Plasma B cells (PC), Breg in splenic leukocytes (SPL). dh Proportion of B220+ cells, CD3+ cells, CD49b+ cells, CD11c+ cells, and CD11b+ cells in leukocytes of spleen, blood, lung, liver, and gut in Erbin full knockout (Erbin−/−) mice. im Proportion of Naive B cells, Memory B cells, Plasma cells (PC), and Breg cells of spleen, blood, lung, liver, and gut in Erbin−/− mice. nr Proportion of Naive B cells, Memory B cells, Plasma cells (PC), and Breg cells of spleen, blood, lung, liver, and gut in cKO mice. st Proportion of IgA+/IgG+/IgM+ CD138+ cells of lung leukocytes in Erbin−/− mice (s) and WT vs cKO mice (t). *p < 0.05 (Student t test)

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