Fig. 3
From: Targeting Erbin in B cells for therapy of lung metastasis of colorectal cancer
The effects of Erbin deletion or adoptive cell transfer therapy using B cell isolated from Erbin deletion mice in lung metastasis mouse model of CRC. a–c, Gross lung appearance (a), H&E (haematoxylin and eosin) staining (b), the numbers of lung metastases (c), were determined in Erbin−/− lung metastasis mouse model of CRC one month after administrated with MC38 cells. d–f Gross lung appearance (d), H&E staining (e), the numbers of lung metastases (f), were determined in Erbin−/− lung metastasis mouse model of CRC one month after administrated with CMT93 cells. g–i Gross lung appearance (g), H&E staining (h), the numbers of lung metastases (i), in WT control, Erbin−/−, RWT (BW) mice one month after administrated with MC38 cells. RWT (BW) mice were WT mice receiving B cells isolated from bone marrow of Erbin−/− mice. j–l Gross lung appearance (j), H&E staining (k), the numbers of lung metastases (l), in WT control, Erbin−/−, RWT (BW), and RWT (SPL) mice 1 month after administrated with MC38 cells. RWT (BW) mice were WT mice receiving B cells from bone marrow of Erbin−/− mice. RWT (SPL) mice were WT mice receiving B cells from spleen of Erbin−/− mice. m–o Gross lung appearance (m), H&E staining (n), the numbers of lung metastases (o), in WT and cKO mice 1 month after administrated with MC38 cells. p Survival curves of WT and Erbin−/− mice within 2 months after administrated with MC38 cells. *p < 0.05 (Student t test)
