Fig. 4

The proportion of IgA+ CD138+ cells in lung metastases of CRC in Erbin-deficient mice. a The percentage of Naive B cells, Memory B cells, Plasma cells, and Breg cells in the lung of tumor-bearing WT and Erbin^−/− mice. b The percentage of IgA⁺ CD138⁺ cells in lung, spleen, and blood leukocytes of tumor-bearing WT and Erbin^−/− mice. c, d The percentage (c) and flow cytometry analysis (d) of IgA⁺/IgG⁺/IgM⁺ CD138⁺ cells in lung leukocytes of tumor-bearing WT and Erbin^−/− mice. e The percentage of Naive B cells, Memory B cells, Plasma cells, and Breg cells in the lung of tumor-bearing WT and cKO mice. f ELISA analysis of serum IgA/IgG/IgM content in tumor-bearing WT and cKO mice. g, h The percentage (g) and flow cytometry analysis (h) of IgA⁺/IgG⁺/IgM⁺ CD138⁺ cells in lung of tumor-bearing WT and cKO mice. i ELISA analysis of the content of IgA, IgG, and IgM in the supernatant of spleen B cells from tumor-bearing WT and cKO mice, which were induced into plasma cells in vitro. *p < 0.05 (Student t test)