Fig. 5
From: Dynamic blood single-cell immune responses in patients with COVID-19
T lymphocytes and B lymphocytes V(D)J clone expansion and TSNE plots of integrated analysis of 5′mRNA, T cell receptor (TCR), and B cell receptors (BCR) of patients with COVID-19. a The number of T cell clones detected by V(D)J in each patient. b The number of T cell clones detected by disease condition and the recovery condition of patients 1, 2, 3, 6, 7, 9, and 10. c The number of B cell clones detected by V(D)J in each patient. d The number of B cell clones detected at disease and recovery conditions of patients 1, 2, 3, 6, 7, 9, and 10. e Clonally related IgH sequences in each patient. f Number of mutations in IgH gene variable regions in different COVID-19 patients. The statistical significance refers to the statistics of different courses of the same patient who had dynamic analysis data. *P < 0.05, **P < 0.01, ***P < 0.001; t-test. g Clonotypic T cells of hospitalized patients. h Clonotypic T cells of cured patients. i Clonotypic B cells of hospitalized patients. j Clonotypic B cells of cured patients. Patients in hospitalized condition: P1-1, P1-2, P2-1, P2-2, P3-1, P6-1, P7-1, P9-1, and P10-1. Patients in cured condition: P1-3, P2-3, P3-2, P6-2, P7-2, P9-2, and P10-2. The detailed cell types of these patients are shown in Fig. 3a. k TSNE plot of a clonotypic T cell (terminal effector CD8 T cells): CVVNYYKAAGNKLTF_CASSLGSAPRELFF (TRAV12-1*01, TRAJ17*01, and TRAC*010 in P2-1, P2-2, and P2-3)
