Fig. 4 | Signal Transduction and Targeted Therapy

Fig. 4

From: An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19

Fig. 4

CVL218 attenuates the LPS-induced cytokine production in a time- and dose-dependent manner. Concentrations of four cytokines (IL-6, IL-10, IFN-γ, and TNF-α) in the LPS-induced peripheral blood mononuclear cells (PMBCs) were measured by ELISA after 6 h and 24 h of drug treatment. Dexamethasone (DEX) in 1 μg/mL was used as a positive control. a–h Concentrations of IL-6 after 6 h (a) and 12 h (b), IL-10 after 6 h (c) and 12 h (d), IFN-γ after 6 h (e) and 12 h (f), and TNF-α after 6 h (g) and 12 h (h) of drug treatment. Results are shown as mean ± SD over three replicates. The significances were measured by p-values from two-tailed t-tests between LPS+ drug and LPS only groups. *, **, ***, and **** stand for p-value < 0.05, 0.01, 0.001, 0.0001, respectively

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