Table 1 Biologically active sequences may be sub-classified into primary sequence recognition sites (in which a receptor directly bind with a specific amino acid sequence or carbohydrate repeats) and secondary and tertiary structures (which depend on molecular conformation, motifs, and domains for recognition).

From: Correction to: Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties

Macro-molecule

Molecule family

Binding Site/ Functional Motif

Receptor

Activated signalling pathway

Downstream effects

Ref.

Silk Fibroin and Sericin

Insoluble fibrous protein

Unknown

RANKL

Inhibition of ERK1/2 signalling

Osteoclastogenesis inhibition

2

  1. Biomaterials contain naturally occurring functional sequences and motifs that bind receptors to induce intracellular signalling and promote downstream effects. (Updated entry only shown here).
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