Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq

Fig. 3

Non-stochastic paired BCR repertoire in convalescent COVID-19 patients. Heatmap showing the paired of immunoglobulin heavy chains and light chains gene variable region segments of clonotypes in convalescent COVID-19 patients. a COVID-19 group. b COVID-19 antigen labeled group (c) healthy donors (HD). Row and column histograms indicate marginal VH and VL frequencies, respectively. The reader color means the higher usage percentage of specific VH-VL gene pairs. Treemap showing usage frequency of specific VH-JH gene pairs in COVID-19 (d). COVID-19 antigen labeled (e) and HD (f). A rectangle in a treemap plot represents a unique combination of VH-JH genes. The size of a rectangle denotes the relative frequency of VH-JH gene pairs. The color of VH-JH gene pairs in each treemap plot was randomly chosen, and thus, the colors do not match between the plots

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