Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Sequential infection with H1N1 and SARS-CoV-2 aggravated COVID-19 pathogenesis in a mammalian model, and co-vaccination as an effective method of prevention of COVID-19 and influenza

Fig. 1

Clinical findings of co-infection with H1N1 and SARS-CoV-2 in ferrets. a Experimental design and sample collection. Eighteen ferrets were used in this study. Six ferrets were inoculated intranasally with H1N1 (1 × 106 TCID50) and rechallenged intranasally with the same dose of SARS-CoV-2 (F/FC group, n = 6). The remaining ferrets were intranasally challenged with H1N1 (F/F group, n = 6) or SARS-CoV-2 (F/C group, n = 6) as control groups. Infected ferrets were observed for changes in body weight (b), body temperature (c), and clinical symptoms (d) at the indicated time points. Significant differences are indicated with asterisks (*P < 0.05, **P < 0.01; Student’s t test)

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