Fig. 5
From: Recent progress in targeted delivery vectors based on biomimetic nanoparticles
Mechanism of delivering siRNA and mRNA for gene therapy based on VNPs. siRNA or mRNA loaded-VNPs can be internalized into the cytoplasm of the target cells via recognition of glycosylated cell surface receptors on the surface of host cells. siRNA released in the cell cytoplasm will bind to RNA-induced silencing complex (RISC) with the target mRNA and knockdown the specific protein expression in cells. The packaged mRNA is translated into protein after its delivery to the cytoplasm
