Fig. 6
From: A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies
DEPTAC improves hippocampus-dependent learning and memory in dox-treated Tau368 mice. a–f 1-month DEPTAC treatment after stopping the dox rescued the hTau-induced object-place (a–c) and novel-object (d–f) recognition impairments in Tau368 mice compared with the vehicle controls. Cartoons (a, d) show paradigms of the behavioral tests. Representative heatmaps (b, e) show the time-location of mice traveled in test chambers. Two-way ANOVA followed by Tukey’s multiple comparisons tests, *p < 0.05, n = 10–15 mice in each group. g DEPTAC significantly alleviated the hTau-induced spatial learning deficits in Morris water maze test. Repeated measures ANOVA followed by Tukey’s multiple comparisons tests, **p < 0.01, *p < 0.05. h, i DEPTAC attenuated spatial memory deficits in dox-treated Tau368 mice shown by the increased time staying in h and number of entries into (i) the target quadrant in water maze test detected at day 6 after removed the platform. Two-way ANOVA followed by Tukey’s multiple comparisons, *p < 0.05. j Representative traces of the mice traveled in the water maze at day 6. Green areas indicate the target quadrants. Data were presented as Min-Median-Max
